Triethylamine → HCID 10224776, compound

HRID 1072677Notes

Reaction equation

HRID 1072677 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:26]=[CH:25][C:13]([O:14][CH:15]([CH3:24])[CH2:16][NH:17][S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:34](Cl)(=[O:38])[CH:35]([CH3:37])[CH3:36]>C(Cl)Cl>[CH3:36][CH:35]([CH3:37])[C:34]([NH:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:26]=[CH:25][C:13]([O:14][CH:15]([CH3:24])[CH2:16][NH:17][S:18]([CH:21]([CH3:22])[CH3:23])(=[O:20])=[O:19])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)=[O:38]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 22388582HCID 22388582, compound

Product 1

HCID 10224776HCID 10224776, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The final title compound (59 mg, 19%) was prepared from (2-{4-[4-(aminomethyl)phenyl]phenoxy}propyl)[(methylethyl)sulfonyl]amine hydrochloride (250 mg, 0.717 mmol, prepared in example 32) methylene chloride (4.6 mL, absolute) triethylamine (0.07 mL, 0.8621 mmol), aind isobutyryl chloride (0.06 mL, 1.0345 mmol), in a manner analogous to Example 29.

Sources & evidence

ORD record
ord-9188f855073346b3a30dce517662cd3f
Source dataset
uspto-grants-2005_06
Patent number
US06911476B2

Reaction notes

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