Triethylamine → HCID 22387601, compound

HRID 1072710Notes

Reaction equation

HRID 1072710 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][OH:14])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].C(N(CC)CC)C.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>C(OCC)(=O)C>[CH3:22][S:23]([O:14][CH2:13][CH2:12][CH2:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[CH:10][CH:9]=1)(=[O:25])=[O:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 22387514HCID 22387514, compound

Product 1

HCID 22387601HCID 22387601, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 3-(4-butylphenyl)propanol (2.86 g, 14.9 mmol) and triethylamine (1.51 g, 14.9 mmol) in ethyl acetate (30 ml) was added methanesulfonyl chloride (1.70 g, 14.9 mmol) and the mixture was stirred at room temperature for 2 hours. The reaction solution was washed with water and saturated brine, dried over magnesium sulfate anhydride and concentrated under reduced pressure to give the object compound as an oily substance. 4.02 g (yield: 100%)

Workup

  1. washThe reaction solution was washed with water and saturated brine
  2. dry with materialdried over magnesium sulfate anhydride
  3. concentrationconcentrated under reduced pressure
  4. customto give the object compound as an oily substance

Sources & evidence

ORD record
ord-30f611ab91f34b618662e220d5388577
Source dataset
uspto-grants-2005_06
Patent number
US06911468B2

Reaction notes

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