反应详情

Methyl 4-hydroxybenzoate (15.52 g), bromoacetaldehyde dimethyl acetal (16.90 g) and 60% sodium hydride (5.00 g) were heated in dimethyl formamide (50 ml) at 80° C. for 18 hr. Dimethyl formamide was distilled away from the reaction mixture, and toluene and water were added. The separated toluene layer was dried over magnesium sulfate, and the solvent was distilled away to give the objective compound (16.00 g).

1. distillationDimethyl formamide was distilled away from the reaction mixture, and toluene and water
2. additionwere added
3. dry with materialThe separated toluene layer was dried over magnesium sulfate
4. distillationthe solvent was distilled away