Dimethylformamide → HCID 15070296, compound

HRID 1073033Notes

Reaction equation

HRID 1073033 reaction equation
CN(C)C=O.[CH3:6][O:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[N:11]=[C:10]([O:16][CH:17]([CH2:21][C:22]2[C:27]([Cl:28])=[CH:26][CH:25]=[CH:24][C:23]=2[Cl:29])[C:18]([OH:20])=[O:19])[N:9]=1.[CH2:30](Br)[CH3:31].C(=O)([O-])[O-].[K+].[K+]>O>[CH3:15][O:14][C:12]1[CH:13]=[C:8]([O:7][CH3:6])[N:9]=[C:10]([O:16][CH:17]([CH2:21][C:22]2[C:23]([Cl:29])=[CH:24][CH:25]=[CH:26][C:27]=2[Cl:28])[C:18]([O:20][CH2:30][CH3:31])=[O:19])[N:11]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 15070499HCID 15070499, compound

Product 1

HCID 15070296HCID 15070296, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

50 ml of a N,N-dimethylformamide solution of 1.65 g of 2 (4,6-dimethoxypyrimidin-2-yl)oxy-3-(2,6-dichlorophenyl)propionic acid, 0.5 g of ethyl bromide 0.6 g of potassium carbonate was stirred at 80° C. for 2 hours under heating. The reaction solution was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed and dried. Then, the solvent was distilled off to obtain colorless crystals.

Workup

  1. temperatureunder heating
  2. extractionextracted with ethyl acetate
  3. washThe ethyl acetate layer was washed
  4. customdried
  5. distillationThen, the solvent was distilled off
  6. customto obtain colorless crystals

Sources & evidence

ORD record
ord-566d15b539e64ead800715665106d026
Source dataset
uspto-grants-1990_11
Patent number
US04968340

Reaction notes

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