Triethylamine → HCID 22158345, compound

HRID 1073150Notes

Reaction equation

HRID 1073150 reaction equation
[O:1]=[C:2]1[N:7]2[C:8]3[C:13]([C:14]([CH2:15][CH2:16][NH2:17])=[C:6]2[CH2:5][CH2:4][CH2:3]1)=[CH:12][CH:11]=[CH:10][CH:9]=3.[Cl-].C[NH2+]C.[CH2:22]([N:24]([CH2:27]C)[CH2:25][CH3:26])C>CN(C)C=O>[CH3:27][N:24]([CH2:25][CH2:26][CH2:5][CH2:4][CH2:3][C:2]([NH:17][CH2:16][CH2:15][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]2[C:2](=[O:1])[CH2:3][CH2:4][CH2:5][C:6]=12)=[O:1])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12954980Dimethylazanium;chlorideHCID 2003009410-(2-Aminoethyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one

Product 1

HCID 22158345HCID 22158345, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

8.9 g (0.022 mole) D4, 3.2 g (0.44 mole) dimethylammonium chloride and 6 g triethylamine were dissolved in 150 ml N,N-dimethylformamide and heated for 6 h at 90° C. The solvent was evaporated in vacuo and the residue extracted with 100 ml chloroform and 100 ml water. The organic layer was separated and dried. The solvent was evaporated and the residue crystallised from ethyl acetate.

Workup

  1. customThe solvent was evaporated in vacuo
  2. extractionthe residue extracted with 100 ml chloroform and 100 ml water
  3. customThe organic layer was separated
  4. customdried
  5. customThe solvent was evaporated
  6. customthe residue crystallised from ethyl acetate

Sources & evidence

ORD record
ord-49d31f61ca904a36a14db9bf918bcf9b
Source dataset
uspto-grants-1990_11
Patent number
US04968699

Reaction notes

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