Dimethylformamide → HCID 22158396, compound

HRID 1073213Notes

Reaction equation

HRID 1073213 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]2[N:9]([CH:10]=1)[C:8]1[CH:11]=[CH:12][CH:13]=[CH:14][C:7]=1[S:6]2)[CH3:2].P(Cl)(Cl)(Cl)=O.[OH-].[NH4+].CN(C)[CH:24]=[O:25]>>[CH:24]([C:10]1[N:9]2[C:5]([S:6][C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=32)=[N:4][C:3]=1[CH2:1][CH3:2])=[O:25]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 14923Ammonium HydroxideHCID 24813Phosphorus oxychlorideHCID 22158391HCID 22158391, compound

Product 1

HCID 22158396HCID 22158396, compound

Conditions

Temperature
50 °C

Procedure

Subsequently, 4.3 g of 2-ethylimidazo[2,1-b]-benzothiazole was added to a solution prepared from 11 g of phosphorus oxychloride and 20 ml of dimethylformamide followed by heating at 50° C. for 2.5 hours. The reaction mixture was poured onto ice water. After neutralizing with ammonium hydroxide, the precipitated crystals were filtered to give 3.88 g of 3-formyl-2-ethylimidazo[2,1-b]benzothiazole.

Workup

  1. additionThe reaction mixture was poured onto ice water
  2. filtrationthe precipitated crystals were filtered

Sources & evidence

ORD record
ord-6325f9055dda4999b0bae75411abaed3
Source dataset
uspto-grants-1990_11
Patent number
US04968708

Reaction notes

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