Dimethylformamide → HCID 22158380, compound

HRID 1073222Notes

Reaction equation

HRID 1073222 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[N:8]([C:9]=1CO)[C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[S:5]2.[H-].[Na+].[CH3:18][O:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](Cl)=[O:23].CN(C)C=[O:32]>>[CH3:18][O:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22]([O:32][C:9]1[N:8]2[C:4]([S:5][C:6]3[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=32)=[N:3][C:2]=1[CH3:1])=[O:23]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 889692-Methoxybenzoyl chlorideHCID 130922Nik 228

Product 1

HCID 22158380HCID 22158380, compound

Procedure

In 50 ml of dry dimethylformamide was suspended 3.00 g of 2-methylimidazo[2,1-b]benzothiazole-3-methanol. Then, 1.12 g of 60% sodium hydride was added to the suspension. After stirring for 30 minutes, 3.00 g of o-methoxybenzoyl chloride was added to the mixture followed by stirring at room temperature for 3 hours. Ice water was added to the reaction solution and the system extracted with chloroform. After the chloroform was removed, 2.60 g of the title compound was obtained.

Workup

  1. stirringby stirring at room temperature for 3 hours
  2. extractionthe system extracted with chloroform
  3. customAfter the chloroform was removed

Sources & evidence

ORD record
ord-29b2fc3f11564b05a80ee2a9188f63ec
Source dataset
uspto-grants-1990_11
Patent number
US04968708

Reaction notes

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