Water → Methyl 4'-(benzyloxy)-[1,1'-biphenyl]-4-carboxylate

HRID 1074304Notes

Reaction equation

HRID 1074304 reaction equation
FC(F)(F)[CH:3]([O:10][C:11]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)C=C(C(Cl)=O)C=C2)=O)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]C.[C:28](=O)([O-])[O-:29].[K+].[K+].[CH2:34](Br)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.[OH2:42]>CN(NC=O)C>[CH3:28][O:29][C:34]([C:35]1[CH:40]=[CH:39][C:38]([C:6]2[CH:5]=[CH:4][C:3]([O:10][CH2:11][C:13]3[CH:22]=[CH:21][CH:20]=[CH:15][CH:14]=3)=[CH:8][CH:7]=2)=[CH:37][CH:36]=1)=[O:42]

Participants

6

Reactant 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 148475736-(1-Trifluoromethylheptyloxycarbonyl)-naphathalene-2-carboxylic acid chloride

Product 1

HCID 15084903Methyl 4'-(benzyloxy)-[1,1'-biphenyl]-4-carboxylate

Reagents, catalysts & solvents 1

HCID 304376N',N'-DimethylformohydrazideSolvent

Conditions

Temperature
110 °C

Procedure

The product obtained in Item (1) in the amount of 4.1 g was dissolved in 100 ml of dimethylaminoformamide. The solution was added with anhydrous potassium carbonate 3.6 g and after heating upto 110° C. dropped with benzyl bromide 4.1 g during one hour to be stirred thereafter at a temperature of 140° C. for 4 hours. The reaction solution was taken into a large amount of water to precipitate crystal, which was dried to obtain the captioned product in the amount of 6.6 g.

Workup

  1. customto precipitate crystal, which
  2. customwas dried
  3. customto obtain the captioned product in the amount of 6.6 g

Sources & evidence

ORD record
ord-e5a603c947234c3a83f61e6dcab751dd
Source dataset
uspto-grants-1990_11
Patent number
US04973738

Reaction notes

Loading…