Hydrochloric Acid → HCID 15860240, compound

HRID 1075376Notes

Reaction equation

HRID 1075376 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:14]1(=O)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.[C-:21]#[N:22].[K+]>O>[C:21]([C:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)#[N:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 70961-PhenylpiperazineHCID 7967CyclohexanoneHCID 9032Potassium Cyanide

Product 1

HCID 15860240HCID 15860240, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Phenylpiperazine (11.3 mL, 12 g, 75 mmol) was suspended in 100 mL water. The pH was adjusted to 3 using 10% HCl. Cyclohexanone (7.8 mL, 7.4 g, 75 mmol) was added followed by KCN (5 g, 75 mmol). The mixture was stirred 15 hours at room temperature during which time the product solidified. The product was collected by filtration, washed with water, then recrystallized from ethanol to give 14.5 g of 1-Cyano-1-(4-phenylpiperazin-1-yl)-cyclohexane as a white solid (73% yield), mp=133-135° C.

Workup

  1. filtrationThe product was collected by filtration
  2. washwashed with water
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-06e4587a270c42f38ccb6a6a66850a3b
Source dataset
uspto-grants-1999_05
Patent number
US05900415

Reaction notes

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