Methyl Chloride → HCID 54240948, compound

HRID 1076500Notes

Reaction equation

HRID 1076500 reaction equation
C(O)(=O)C(O)=O.[CH3:7][N:8]([CH3:34])[CH2:9][CH2:10][CH2:11][N:12]1[CH:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]2[C:14]([C:15](=[CH:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:16][CH2:17][CH2:18]2)=[N:13]1.C([O-])([O-])=O.[K+].[K+].CCl>CC#N>[CH3:34][N:8]([CH3:7])[CH2:9][CH2:10][CH2:11][N:12]1[CH:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:19]2[C:14]([C:15](=[CH:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:16][CH2:17][CH2:18]2)=[N:13]1

Participants

5

Reactant 3

HCID 6327Methyl ChlorideHCID 11430Potassium CarbonateHCID 131710231HCID 131710231, compound

Product 1

HCID 54240948HCID 54240948, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The oxalate salt of example 1 is basified by treatment with K2CO3. A solution of the base in MeCN is cooled and treated with methyl chloride. The solution is allowed to stand for one day and the solvent is evaporated to give 3,3a,4,5,6,7-hexahydro-N,N-dimethyl-3-phenyl-7-(phenylmethylene)-2H-indazole-2-propanamine, methochloride.

Workup

  1. customthe solvent is evaporated

Sources & evidence

ORD record
ord-cfee91b4c2424430895317e4821f5edd
Source dataset
uspto-grants-1976_05
Patent number
US03957762

Reaction notes

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