反应详情

N-3,3-Diphenylpropylpiperazine in the amount of 14.0 g (0.05 mole), 10.8 g (0.05 mole) of 3,4,5-trimethoxybenzylchloride, and 5.05 g (0.05 mole) of triethylamine were dissolved in 100 ml of xylene, and the same procedure as that of Example 1 was followed to obtain 20.4 g of 1-(3,3-diphenylpropyl)-4-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (76.7% yield) with a melting point of 178°C.