Triethylamine → 5-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]pentanamide

HRID 1078388Notes

Reaction equation

HRID 1078388 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](Cl)=[O:19].C(N(CC)CC)C>ClCCl>[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH:12][C:9]([C:6]1[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=1)([CH3:10])[CH3:11])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 740895-Chlorovaleryl chlorideHCID 451583372-(4-Chlorophenyl)propan-2-amine hydrochloride

Product 1

HCID 194295005-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]pentanamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(4-Chlorophenyl)-1-methylethylamine hydrochloride (4.0 g) was reacted with 5-chloropentanoyl chloride (3.0 g) in dichloromethane (15 ml) containing triethylamine (8.1 ml) in a similar manner to Example 52b, to give 5-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]pentanamide.

Sources & evidence

ORD record
ord-27617f1506a84f9c8f93f0643724d8d4
Source dataset
uspto-grants-1996_08
Patent number
US05547972

Reaction notes

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