反应详情

A mixture of 4-hydroxy-2-methoxybenzaldehyde (5.23 g; 34.4 mmol), t-butyl bromoacetate (4.9 mL; 30.3 mmol) and K2CO3 (15.1 g; 108.9 mmol) in 50 mL of DMF was stirred at room temperature for 16 hours. The reaction mixture was diluted with ethyl acetate, filtered, and partitioned between ethyl acetate and 1 N HCl. The organic phase was washed (sat. NaCl) and dried (MgSO4), and concentrated to give 17.59 g of t-butyl 4-formyl-3-methoxyphenoxyacetate as a white solid.

1. filtrationfiltered
2. custompartitioned between ethyl acetate and 1 N HCl
3. washThe organic phase was washed (sat. NaCl)
4. dry with materialdried (MgSO4)
5. concentrationconcentrated