Triethylamine → HCID 23365534, compound

HRID 1080674Notes

Reaction equation

HRID 1080674 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH3:12])[CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.Cl.[CH3:21][O:22][C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][C:32]=1[O:33][CH3:34])[CH2:29][NH:28][CH2:27][CH2:26]2.C(N(CC)CC)C>CC(N(C)C)=O>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH3:12])[CH:7]=[N:8]2)=[C:4]([N:28]2[CH2:27][CH2:26][C:25]3[C:30](=[CH:31][C:32]([O:33][CH3:34])=[C:23]([O:22][CH3:21])[CH:24]=3)[CH2:29]2)[N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 64560356,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 23365535HCID 23365535, compound

Product 1

HCID 23365534HCID 23365534, compoundYield 38.4%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Employing the procedure of Preparation B, 730 mg of 2,6-dichloro-7-(1-phenylethyl)purine, 573 mg of 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride and 505 mg of triethylamine in 25 ml of dimethylacetamide gave 430 mg of the desired intermediate.

Sources & evidence

ORD record
ord-fe37add70d7e4222901a424290924231
Source dataset
uspto-grants-1996_12
Patent number
US05583137

Reaction notes

Loading…