Hydrochloric Acid → HCID 11012022, compound

HRID 1080841Notes

Reaction equation

HRID 1080841 reaction equation
[C:1]([NH:8][C@H:9]([C:11]([OH:13])=O)[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[OH2:14].ON1[C:20]2[CH:21]=[CH:22][CH:23]=C[C:19]=2[N:18]=N1.Cl.CN1C[CH2:31][O:30]CC1>CN(C=O)C.O>[CH3:31][O:30][C:23](=[O:14])[C@@H:22]1[CH2:21][CH2:20][CH2:19][N:18]1[C:11](=[O:13])[C@H:9]([CH3:10])[NH:8][C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 79724-MethylmorpholineHCID 85082Tert-butoxycarbonylalanineHCID 27960291-Hydroxybenzotriazole hydrate

Product 1

HCID 11012022HCID 11012022, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of N-BOC-L-alanine (150 mmol) in DMF (250 mL) at 0° C., is added proline methyl ester. HCl (150 mmol), 1-hydroxybenzotriazole hydrate (22.2 g, 0.164 mmol), ethyl-3-(3-dimethylamino)propyl carbodiimide.HCl (31.4 g, 0.164 mmol) and 4-methylmorpholine (22.6 g, 0.224 mmol). The reaction mixture is stirred for 12 h while allowing the reaction to warm to room temperature. The reaction mixture is poured in water (750 mL) and extracted with ethyl acetate (2×150 mL). The combined organic extracts are washed as follows: KHSO4 (0.25M, 2×50 mL), water (1×50 mL), saturated aqueous NaHCO3 (2×50 mL) and saturated NaCl (1×50 mL). The organic layer is dried over MgSO4, filtered and the solvent removed in vacuo to give title compound.

Workup

  1. customthe reaction
  2. extractionextracted with ethyl acetate (2×150 mL)
  3. washThe combined organic extracts are washed
  4. dry with materialThe organic layer is dried over MgSO4
  5. filtrationfiltered
  6. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-a51f3375bea8492ca83b8798d03cc1b0
Source dataset
uspto-grants-1996_12
Patent number
US05583146

Reaction notes

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