2-Bromobiphenyl → HCID 178481277, compound

HRID 1082927Notes

Reaction equation

HRID 1082927 reaction equation
Brc1ccccc1-c1ccccc1.Cn1cnc(C#N)c1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].COc1ccc(OC)c(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.[K+]>Cn1cnc(C#N)c1-c1ccccc1-c1ccccc1

Participants

8

Reactant 2

HCID 163292-BromobiphenylHCID 27951151-Methyl-1H-imidazole-4-carbonitrile

Product 1

HCID 178481277HCID 178481277, compoundYield 23.17%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 44597232Bis(3,5-bis(trifluoromethyl)phenyl)(3,6-dimethoxy-2',4',6'-tri(propan-2-yl)(1,1'-biphenyl)-2-yl)phosphaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-738b1166f0f846ba80cf95173f5454c7
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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