Benzofuran, 5-bromo- → HCID 178506399, compound

HRID 1083168Notes

Reaction equation

HRID 1083168 reaction equation
Brc1ccc2occc2c1.FC(F)n1ccnc1-c1ccccc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].FC(F)(F)c1cc(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc(C(F)(F)F)c1.[K+]>FC(F)n1c(-c2ccc3occc3c2)cnc1-c1ccccc1

Participants

8

Reactant 2

HCID 90015Benzofuran, 5-bromo-HCID 534857661-(Difluoromethyl)-2-phenyl-1H-imidazole

Product 1

HCID 178506399HCID 178506399, compoundYield 74.77%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 2778032Tris[3,5-bis(trifluoromethyl)phenyl]phosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-4538a1d2c9554e60b1cfa21328aab720
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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