2-Bromobiphenyl → HCID 178456431, compound

HRID 1083399Notes

Reaction equation

HRID 1083399 reaction equation
Brc1ccccc1-c1ccccc1.CC(C)n1ccnc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CCCCC1(P(C2CCCCC2)C2CCCCC2)c2ccccc2-c2ccccc21.[K+]>CC(C)n1cncc1-c1ccccc1-c1ccccc1

Participants

8

Reactant 2

HCID 163292-BromobiphenylHCID 101761131H-Imidazole, 1-(1-methylethyl)-

Product 1

HCID 178456431HCID 178456431, compoundYield 0.34%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 71310598(9-Butylfluoren-9-yl)-dicyclohexylphosphaneCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-3b2d3b32a56e4b02ac57eb95deb4cb8b
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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