1-Bromo-2-fluorobenzene → HCID 178510011, compound

HRID 1083683Notes

Reaction equation

HRID 1083683 reaction equation
Fc1ccccc1Br.N#Cc1ccc(-n2ccnc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.[K+]>N#Cc1ccc(-n2cncc2-c2ccccc2F)cc1

Participants

8

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 135744Benzonitrile, p-imidazol-1-yl-

Product 1

HCID 178510011HCID 178510011, compoundYield 3.7%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-5e375b27323a4646a54cd616f4e3cdc8
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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