Benzonitrile, p-imidazol-1-yl- → HCID 178468654, compound

HRID 1083731Notes

Reaction equation

HRID 1083731 reaction equation
CCOC(=O)c1cc(Br)cn1CC.N#Cc1ccc(-n2ccnc2)cc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.[K+]>CCOC(=O)c1cc(-c2cncn2-c2ccc(C#N)cc2)cn1CC

Participants

8

Reactant 2

HCID 135744Benzonitrile, p-imidazol-1-yl-HCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

Product 1

HCID 178468654HCID 178468654, compoundYield 5.95%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-2060cd6a7ccf4ebb90a32a9c08fc500d
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

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