2-Bromobiphenyl → HCID 178506400, compound

HRID 1083845Notes

Reaction equation

HRID 1083845 reaction equation
Brc1ccccc1-c1ccccc1.FC(F)n1ccnc1-c1ccccc1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CN(C)c1cccc(N(C)C)c1-c1ccccc1P(c1ccccc1)C(C)(C)C.[K+]>FC(F)n1c(-c2ccccc2-c2ccccc2)cnc1-c1ccccc1

Participants

8

Reactant 2

HCID 163292-BromobiphenylHCID 534857661-(Difluoromethyl)-2-phenyl-1H-imidazole

Product 1

HCID 178506400HCID 178506400, compoundYield 12.13%

Reagents, catalysts & solvents 5

HCID 23662159Potassium TrimethylacetateReagentHCID 1212377832'-[(1,1-Dimethylethyl)phenylphosphino]-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 31374DimethylacetamideSolvent3×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
120 °C

Workup

  1. temperatureCool to room temperature
  2. additionNo procedure recorded
  3. aliquotNo procedure recorded
  4. filtrationFilter into HPLC analysis plate · Keep liquid/mobile
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

Sources & evidence

ORD record
ord-b0f8c240b5a44b858736305d13d98c25
Source dataset
Pd-catalyzed C-H arylation of imidazole with aryl bromide
Original link
View source

Reaction notes

Loading…