Triethylamine → 5-(Dimethylphosphoryl)-3-phenyl-4,5-dihydro-1,2-oxazole

HRID 1084796Notes

Reaction equation

HRID 1084796 reaction equation
[CH:1](=[N:8][OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClN1C(=O)CCC1=O.[CH:18]([P:20](=[O:23])([CH3:22])[CH3:21])=[CH2:19].C(N(CC)CC)C>>[C:2]1([C:1]2[CH2:19][CH:18]([P:20](=[O:23])([CH3:22])[CH3:21])[O:9][N:8]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 12143(Z)-Benzaldehyde oximeHCID 31398ChlorosuccinimideHCID 129438702180-73-6

Product 1

HCID 30794215-(Dimethylphosphoryl)-3-phenyl-4,5-dihydro-1,2-oxazoleYield 57.7%

Procedure

Preparation is carried out in analogy to Example 1 by starting from 60.6 g (0.5 mol) of benzaldoxime, 73.45 g (0.55 mol) of N-chlorosuccinimide, 57.3 g (0.55 mol) of vinyldimethylphosphine oxide and 76.5 ml (0.55 mol) of triethylamine. After the usual working up, the product is recrystallized from. tert.butyl methyl ether. 64.4 g of pure product of melting point 153° C. are obtained.

Workup

  1. customPreparation
  2. customthe product is recrystallized from

Sources & evidence

ORD record
ord-b6549457d173468b816b8214d4c2a375
Source dataset
uspto-grants-1991_04
Patent number
US05006515

Reaction notes

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