反应详情

温度

60 °C

Ethyl 6,7,8-trifluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate (0.33 g) and 0.14 g of potassium carbonate were suspended in 10 ml of N,N-dimethylformamide, 0.13 g of anhydrous piperazine was added and the mixture was stirred at 60° C. for 2 hours. N,N-Dimethylformamide was evaporated therefrom in vacuo, the residue was dissolved in chloroform, the solution was washed with water, dried over magnesium sulfate, the solvent was evaporated therefrom, the residue was subjected to a silica gel column chromatography (30 g of Wakogel C-300 being used) and eluted with chloroform-methanol (4:1) to give 0.29 g of the title product, m.p. 195°-198° C. (decompn).

1. customN,N-Dimethylformamide was evaporated
2. dissolutionin vacuo, the residue was dissolved in chloroform
3. washthe solution was washed with water
4. dry with materialdried over magnesium sulfate
5. customthe solvent was evaporated
6. washeluted with chloroform-methanol (4:1)