Heptanol → HCID 14717231, compound

HRID 1085886Notes

Reaction equation

HRID 1085886 reaction equation
[H-].[Na+].[NH2:3][C:4]1[N:9]=[C:8]([F:10])[CH:7]=[C:6](F)[N:5]=1.[CH2:12]([OH:19])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>>[NH2:3][C:4]1[N:9]=[C:8]([F:10])[CH:7]=[C:6]([O:19][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[N:5]=1

Participants

4

Reactant 3

HCID 8129Heptanol2×HCID 24758Sodium hydrideHCID 12014802-Amino-4,6-difluoropyrimidine

Product 1

HCID 14717231HCID 14717231, compound

Procedure

A solution of 1.14 g (0.038 mol) of 80% sodium hydride (suspension in linseed oil) in 30 ml of n-heptanol was added to a stirred mixture of 5 g (0.038 mol) of 2-amino-4,6-difluoropyrimidine in 70 ml of n-heptanol at 20° to 25° C. within 5 minutes. After 2.5 hours working up was carried out as in Example 6. 6.3 g (73% of theory) of the title compound of melting point 30°-32° C. were obtained in this way.

Sources & evidence

ORD record
ord-0875f357626d40cd91398c7fdfbc0cc3
Source dataset
uspto-grants-1991_04
Patent number
US05011927

Reaction notes

Loading…