HRID1086126

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8021

Diethylamine

C4H11N

结构：CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(C)C)C(=O)OCc1ccccc1

HCID178455925

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)C(C)C)C(=O)OCc1ccccc1

HCID178455924

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

31.5 ml of diethylamine are added to a solution of 21 g (30 mmol) of Fmoc-Val-Arg-Ile-OBzl in 200 ml of dimethylformamide. The mixture is left to stand at room temperature for 10 minutes, and is concentrated in vacuo. The residue is triturated with diethyl ether and filtered off with suction.

WORKUP

后处理

waitThe mixture is left
concentrationis concentrated in vacuo
customThe residue is triturated with diethyl ether
filtrationfiltered off with suction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-13a7e8668c1f49ed8ccba1ad01d60636
来源数据集: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05011825
来源说明: uspto-grants-1991_04

反应 SMILES

C(NCC)C.[NH:6](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:7]([C:11]([NH:13][C@H:14]([C:22]([NH:24][C@H:25]([C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:21])[NH2:20])=[O:12])[CH:8]([CH3:10])[CH3:9]>CN(C)C=O>[NH2:6][C@H:7]([C:11]([NH:13][C@H:14]([C:22]([NH:24][C@H:25]([C:30]([O:32][CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:20])[NH2:21])=[O:12])[CH:8]([CH3:10])[CH3:9]