Diethylamine → HCID 178455924, compound

HRID 1086126Notes

Reaction equation

HRID 1086126 reaction equation
C(NCC)C.[NH:6](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:7]([C:11]([NH:13][C@H:14]([C:22]([NH:24][C@H:25]([C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:21])[NH2:20])=[O:12])[CH:8]([CH3:10])[CH3:9]>CN(C)C=O>[NH2:6][C@H:7]([C:11]([NH:13][C@H:14]([C:22]([NH:24][C@H:25]([C:30]([O:32][CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:20])[NH2:21])=[O:12])[CH:8]([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 178455925HCID 178455925, compound

Product 1

HCID 178455924HCID 178455924, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

31.5 ml of diethylamine are added to a solution of 21 g (30 mmol) of Fmoc-Val-Arg-Ile-OBzl in 200 ml of dimethylformamide. The mixture is left to stand at room temperature for 10 minutes, and is concentrated in vacuo. The residue is triturated with diethyl ether and filtered off with suction.

Workup

  1. waitThe mixture is left
  2. concentrationis concentrated in vacuo
  3. customThe residue is triturated with diethyl ether
  4. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-13a7e8668c1f49ed8ccba1ad01d60636
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

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