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HRID1086128

反应详情

EQUATION

反应方程式

HRID 1086128 的结构方程式

REACTANTS

反应物

5
结构：CCN1CCOCC1
HCID7525

N-Ethylmorpholine

C6H13NO

结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)(C)SSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID16213190

3-((1,1-Dimethylethyl)dithio)-N-((9H-fluoren-9-ylmethoxy)carbonyl)-L-alanine

C22H25NO4S2

结构：CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCNC(=N)N
HCID178451187

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O.CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CSSC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21
HCID178476288

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

2.2 g of DCC are added, at 0° C., to a stirred solution of 4.31 g (10 mmol) of Fmoc-Cys(StBu)--OH, 7.74 g of H-Arg-Phe-OtBu.2 HClO4 (oily substance obtained above), 1.35 g of HOBt and 1.3 ml of N-ethylmorpholine in 40 ml of dimethylformamide. The mixture is worked up in analogy to Example 1a. The residue is triturated with diethyl ether and dried.

WORKUP

后处理

  1. customThe residue is triturated with diethyl ether
  2. customdried