Diethylamine → HCID 178446035, compound

HRID 1086130Notes

Reaction equation

HRID 1086130 reaction equation
C(NCC)C.[NH:6](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@@H:7]([C:12]([NH:14][C@H:15]([C:23]([NH:25][C@@H:26]([C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[CH:27]([CH3:29])[CH3:28])=[O:24])[CH2:16][CH2:17][CH2:18][NH:19][C:20](=[NH:22])[NH2:21])=[O:13])[CH2:8][CH:9]([CH3:11])[CH3:10]>CN(C)C=O>[NH2:6][C@@H:7]([C:12]([NH:14][C@H:15]([C:23]([NH:25][C@@H:26]([C:30]([O:32][CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)=[O:31])[CH:27]([CH3:29])[CH3:28])=[O:24])[CH2:16][CH2:17][CH2:18][NH:19][C:20](=[NH:21])[NH2:22])=[O:13])[CH2:8][CH:9]([CH3:10])[CH3:11]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 178446038HCID 178446038, compound

Product 1

HCID 178446035HCID 178446035, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

12.05 ml of diethylamine are added to a solution of 8.04 g (11.5 mmol) of Fmoc-D-Leu-Arg-D-Val-OBzl in 60 ml of dimethylformamide. The mixture is left to stand at room temperature for 15 minutes, and is concentrated. The residue is partitioned between n-pentanol and NaHCO3 solution. The pentanol phase is concentrated, and the residue is triturated with diethyl ether.

Workup

  1. waitThe mixture is left
  2. concentrationis concentrated
  3. customThe residue is partitioned between n-pentanol and NaHCO3 solution
  4. concentrationThe pentanol phase is concentrated
  5. customthe residue is triturated with diethyl ether

Sources & evidence

ORD record
ord-24a30bd4d6934c87b1cf7d6f453e1400
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

Loading…