Triethylamine → HCID 14483347, compound

HRID 1086623Notes

Reaction equation

HRID 1086623 reaction equation
[N+:1]([C:4]1[CH:27]=[CH:26][C:7]([CH2:8][O:9][C:10](=[O:25])[C@H:11]([CH2:23]Br)[NH:12][C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(N(CC)CC)C>O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][O:9][C:10](=[O:25])[C:11](=[CH2:23])[NH:12][C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:14])=[CH:26][CH:27]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 18646051HCID 18646051, compound

Product 1

HCID 14483347HCID 14483347, compoundYield 101%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 20 ml solution of 2.18 g (5 mmols) N-carbobenzoxy-β-bromoalanine p-nitrobenzyl ester in tetrahydrofuran, 1.01 g (10 mmols) triethylamine was added and the mixture was stirred at room temperature for 30 minutes. Solvent was removed under reduced pressure, water was added and the crystals which formed were filtered to obtain 1.80 g (yield 100%) of the desired compound.

Workup

  1. customSolvent was removed under reduced pressure, water
  2. additionwas added
  3. customthe crystals which formed
  4. filtrationwere filtered

Sources & evidence

ORD record
ord-d8b33bb7781b49f9a59cedbd35c2f551
Source dataset
uspto-grants-1991_07
Patent number
US05030732

Reaction notes

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