Methyl iodide → HCID 14986888, compound

HRID 1086838Notes

Reaction equation

HRID 1086838 reaction equation
[CH2:1]([N:8]1[C:13]2=[N:14][N:15]3[CH:19]=[C:18]([CH2:20][CH2:21][CH2:22][CH3:23])[NH:17][C:16]3=[C:12]2[C:11](=[O:24])[N:10]([CH2:25][CH2:26][CH3:27])[C:9]1=[O:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]([O-])([O-])=O.[K+].[K+].CI>CN(C=O)C>[CH2:1]([N:8]1[C:13]2=[N:14][N:15]3[CH:19]=[C:18]([CH2:20][CH2:21][CH2:22][CH3:23])[N:17]([CH3:29])[C:16]3=[C:12]2[C:11](=[O:24])[N:10]([CH2:25][CH2:26][CH3:27])[C:9]1=[O:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178441235HCID 178441235, compound

Product 1

HCID 14986888HCID 14986888, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In DMF (20 ml) was dissolved 1-benzyl-6-butyl-3-propyl-1,2,3,4-tetrahydro-5H-imidazo [2',1':5,1]pyrazolo[3,4-d]pyrimidine-2,4-dione (0.5 g). To the solution were added, at room temperature, K2CO3 (0.5 g) and methyl iodide (0.5 g). The mixture was stirred for 8 hours and concentrated to dryness. To the residue was added water, then precipitating crystals were recrystallized from aqueous methanol to give colorless crystals (0.51 g, 98%), m.p. 139°-140° C.

Workup

  1. additionTo the solution were added, at room temperature
  2. concentrationconcentrated to dryness
  3. additionTo the residue was added water
  4. customprecipitating crystals
  5. customwere recrystallized from aqueous methanol

Sources & evidence

ORD record
ord-98024a1c48864ad4ad933a4acb38b79d
Source dataset
uspto-grants-1991_07
Patent number
US05032594

Reaction notes

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