Hydrochloric Acid → 4.5-Dibromothiophene-2-carboxylic acid-N-ethoxyamide

HRID 1086956Notes

Reaction equation

HRID 1086956 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8](Cl)=[O:9])[S:5][C:6]=1[Br:7].Cl.[CH2:12]([O:14][NH2:15])[CH3:13].Cl>N1C=CC=CC=1.O1CCCC1>[CH2:12]([O:14][NH:15][C:8]([C:4]1[S:5][C:6]([Br:7])=[C:2]([Br:1])[CH:3]=1)=[O:9])[CH3:13]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 76850O-ethylhydroxylamine hydrochlorideHCID 134189874,5-Dibromothiophene-2-carbonyl chloride

Product 1

HCID 148824044.5-Dibromothiophene-2-carboxylic acid-N-ethoxyamide

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 8028TetrahydrofuranSolvent

Procedure

At room temperature, 6.8 g of 4.5-dibromothiophene-2-carboxylic chloride is stirred, in portions, into 6.8 g of O-ethylhydroxylamine hydrochloride in 10 ml of pyridine and 80 ml of tetrahydrofuran. After 30 minutes, dilute hydrochloric acid was added, and the product was filtered off and washed with water. Yield: 5.8 g; m.p.: 117-119° C.

Workup

  1. filtrationthe product was filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-5baa1b073a42465887f7dd68d8191e47
Source dataset
uspto-grants-1991_07
Patent number
US05034049

Reaction notes

Loading…