Potassium Acetate → HCID 10758857, compound

HRID 1087029Notes

Reaction equation

HRID 1087029 reaction equation
Br[CH2:2][C:3]1[CH:15]=[C:14]2[C:6]([C:7]3[CH:8]=[C:9]([Br:17])[CH:10]=[CH:11][C:12]=3[C:13]2=[O:16])=[CH:5][CH:4]=1.[C:18]([O-:21])(=[O:20])[CH3:19].[K+]>CN(C=O)C.C(OCC)(=O)C>[Br:17][C:9]1[CH:10]=[CH:11][C:12]2[C:13](=[O:16])[C:14]3[C:6]([C:7]=2[CH:8]=1)=[CH:5][CH:4]=[C:3]([CH2:2][O:20][C:18](=[O:21])[CH3:19])[CH:15]=3

Participants

5

Reactant 2

HCID 517044Potassium AcetateHCID 10665658HCID 10665658, compound

Product 1

HCID 10758857HCID 10758857, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
100 °C

Procedure

7-Bromomethyl-3-bromo-9-fluorenone (1.7 g) was suspended in DMF (25 ml). To this suspension was added potassium acetate (576 mg). The reaction mixture was stirred at 100° C. for one hour. It was then diluted with ethyl acetate, washed four times with water, twice with brine, dried and evaporated. The residue was chromaographed on silica gel using 2% ethyl acetate/methylene chloride which gave the desired product (1.18 g).

Workup

  1. washwashed four times with water
  2. dry with materialtwice with brine, dried
  3. customevaporated

Sources & evidence

ORD record
ord-2e786f139df54aefad0957512be4ea7b
Source dataset
uspto-grants-1991_07
Patent number
US05034384

Reaction notes

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