Hydrochloric Acid → 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oxime

HRID 1087164Notes

Reaction equation

HRID 1087164 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([C:7](=[N:16][OH:17])[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.CC(C)([O-])C.[K+].Cl[CH2:27][C:28](=[O:35])[CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31].Cl>CN(C)C=O>[CH2:33]([O:32][C:30]([CH2:29][C:28](=[O:35])[CH2:27][O:17][N:16]=[C:7]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:6]1[CH:18]=[CH:19][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:31])[CH3:34]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 69484Ethyl 4-chloroacetoacetateHCID 289718n-Hydroxy-1,1-bis(4-methoxyphenyl)methanimine2×HCID 23665647Potassium tert-butoxide

Product 1

HCID 140527694,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oximeYield 80.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.57 g (0.01 mol) of the 4,4'-dimethoxybenzophenone oxime as obtained in (1) was dissolved in 5 ml of dimethylformamide and 1.2 g of potassium tert-butoxide was added thereto under ice cooling. The resulting mixture was stirred for ten minutes. Then 1.8 g of ethyl 4-chloroacetoacetate was added thereto and the obtained mixture was stirred at room temperature. After two hours, the reaction mixture was poured into diluted hydrochloric acid and extracted with ethanol. The crude product thus obtained was purified by silica gel chromatography to give 3.1 g of the title compound.

Workup

  1. stirringthe obtained mixture was stirred at room temperature
  2. extractionextracted with ethanol
  3. customThe crude product thus obtained
  4. customwas purified by silica gel chromatography

Sources & evidence

ORD record
ord-6a7b64f38ba445e09d3c09bad16d1050
Source dataset
uspto-grants-1991_07
Patent number
US05034418

Reaction notes

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