Dimethyl Sulfate → HCID 19816871, compound

HRID 1087377Notes

Reaction equation

HRID 1087377 reaction equation
[CH3:1][C:2]1([CH3:22])[N:7]=[C:6]([O:8][C:9]2[N:10]=[N:11][C:12]([OH:15])=[CH:13][CH:14]=2)[C:5]2[CH:16]=[C:17]([C:20]#[N:21])[CH:18]=[CH:19][C:4]=2[O:3]1.[C:23]([O-])([O-])=O.[K+].[K+].S(OC)(OC)(=O)=O>CN(C=O)C>[CH3:1][C:2]1([CH3:22])[N:7]=[C:6]([O:8][C:9]2[N:10]=[N:11][C:12]([O:15][CH3:23])=[CH:13][CH:14]=2)[C:5]2[CH:16]=[C:17]([C:20]#[N:21])[CH:18]=[CH:19][C:4]=2[O:3]1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 178430675HCID 178430675, compound

Product 1

HCID 19816871HCID 19816871, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 296 mg of 2,2-dimethyl-4-(6-hydroxy-3-pyridazinyloxy)-6-cyano-2H-1,3-benzoxazine, 1 g of K2CO3,0.65 ml of dimethyl sulfate and 16 ml of DMF is boiled for 3 hours and subjected to customary work-up. 2,2-Dimethyl-4-(6-methoxy-3-pyridazinyloxy)-6-cyano-2H-1,3-benzoxazine is obtained.

Sources & evidence

ORD record
ord-b0758b595fb545ba849d041fb95e4d23
Source dataset
uspto-grants-1991_07
Patent number
US05036068

Reaction notes

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