2-Bromoanisole → 2-Bromo-2'-methoxybenzophenone

HRID 1087717Notes

Reaction equation

HRID 1087717 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Mg].[Br:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>>[Br:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9])=[O:15]

Participants

4

Reactant 3

HCID 113582-BromoanisoleHCID 235422-Bromobenzoyl chlorideHCID 5462224Magnesium

Product 1

HCID 157185412-Bromo-2'-methoxybenzophenoneYield 66%

Procedure

Following the Procedure described in Preparation VIa and starting from 9.4 g (0.050 mol) of 2-bromoanisole, 1.7 g (0.069 mol) of magnesium and 11 g (0.050 mol) of 2-bromobenzoyl chloride, 9.6 g of the expected product (yield: 66%) are obtained after crystallization from ether.

Workup

  1. customdescribed in Preparation VIa and

Sources & evidence

ORD record
ord-d2ac9a5aa2f943c19f92ca55bc0d0cbf
Source dataset
uspto-grants-1990_10
Patent number
US04960758

Reaction notes

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