Water → HCID 22163866, compound

HRID 1087768Notes

Reaction equation

HRID 1087768 reaction equation
[N:1]1([CH:6]([F:17])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])=O)[CH:5]=[N:4][CH:3]=[N:2]1.[C:18](=O)([O-])[O-].[K+].[K+].O>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O1CCOCC1>[F:16][C:10]1[CH:11]=[C:12]([F:15])[CH:13]=[CH:14][C:9]=1[C:7]([CH:6]([F:17])[N:1]1[CH:5]=[N:4][CH:3]=[N:2]1)=[CH2:18]

Participants

6

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 22163865HCID 22163865, compound

Product 1

HCID 22163866HCID 22163866, compound

Reagents, catalysts & solvents 2

HCID 74505Methyltriphenyliphosphonium bromideCatalystHCID 312751,4-DioxaneSolvent

Procedure

2-(1H-1,2,4-Triazol-1-yl)-2,2',4'-trifluoroacetophenone (10 g), anhydrous potassium carbonate (7.3 g), and methyltriphenylphosphonium bromide (15.5 g) were heated under reflux for 16 hours in 1,4-dioxan (250 ml), to which water (1.0 g) had been added.

Workup

  1. additionhad been added

Sources & evidence

ORD record
ord-03b76d36c6194f70b7d938ca200e7831
Source dataset
uspto-grants-1990_10
Patent number
US04960782

Reaction notes

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