1-(2-Methoxyphenyl)piperazine → HCID 14763470, compound

HRID 1087832Notes

Reaction equation

HRID 1087832 reaction equation
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17](F)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7].CN(CCN)C.[CH3:28][O:29]C1C=CC=CC=1N1CCNCC1>O1CCCC1>[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:29][CH3:28])[CH2:10][CH2:9]1)=[O:7]

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 66053N,N-DimethylethylenediamineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

Product 1

HCID 14763470HCID 14763470, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 4.9 g (0.03 mole) of 1,1'-carbonydiimidazole, 2.6 g (0.03 mole) of unsym-dimethylethylenediamine and 5.8 g (0.03 mole) of 1-(2-methoxyphenyl)piperazine in a total volume of 200 ml of tetrahydrofuran gave an oil which solidified. After trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from benzene-petroleum ether to yield 4.5 g (49%) of the title compound as an off-white solid, m.p. 98°-100° C.

Workup

  1. customThis compound was prepared
  2. customgave an oil which
  3. customAfter trituration with petroleum ether (30°-60° C.), the collected solid was recrystallized from benzene-petroleum ether

Sources & evidence

ORD record
ord-8878e9c309134cd2a72f21cc34af644f
Source dataset
uspto-grants-1990_10
Patent number
US04960776

Reaction notes

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