Potassium Carbonate → HCID 54541299, compound

HRID 1088448Notes

Reaction equation

HRID 1088448 reaction equation
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:11]=[CH:12][CH:13]=1.[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:29][C:28]([O:27][CH3:26])=[O:31]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

Product 1

HCID 54541299HCID 54541299, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A suspension of milled potassium carbonate (0.5 g), quinoline from Step 2 (1.1 g), and methylbromoacetate (4.0 ml) in acetone (25 ml) were refluxed overnight. The reaction mixture is poured onto water, extracted with ethyl acetate dried and evaporated. Chromatography of the residue on SiO2 using 30 to 40% ether/hexane afforded the title compound: m.p. 110-112°.

Workup

  1. temperaturewere refluxed overnight
  2. additionThe reaction mixture is poured onto water
  3. extractionextracted with ethyl acetate
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-b7a841ca62e44bfca5a60744eacba619
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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