Ammonia → HCID 14836045, compound

Temperature

0 °C

1-Hydroxybenzotriazole (0.84 g, 1.5 eq) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.96 g, 1.2 eq) were added to a stirred solution of N-[[2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine (1.50 g, 4.15 mmol) in anhydrous DMF (15 mL) at room temperature under a dry nitrogen atmosphere. After 13/4 hours, a saturated solution of ammonia in tetrahydrofuran (100 mL) was added to the reaction mixture at room temperature. After 1 hour, the reaction was cooled to 0° C. and ammonia gas was bubbled directly into the reaction mixture for 15 minutes. While still cool, the reaction mixture was filtered and the solid was washed with THF (2×10 mL). The solvent was removed from the filtrate and the residue was diluted with water (500 mL). The aqueous phase was extracted with ether (6×100 mL). The extracts were combined and preabsorbed onto silica gel. The absorbate was flash chromatographed (19:1 chloroform:methanol, silica) and the resulting product was re-flash chromatographed (chloroform to 49:1 chloroform:methanol, silica) to provide the title compound as a light yellow solid (0.30 g, 20%), m.p. 222°-224° C.

1. customammonia gas was bubbled directly into the reaction mixture for 15 minutes
2. temperatureWhile still cool
3. filtrationthe reaction mixture was filtered
4. washthe solid was washed with THF (2×10 mL)
5. customThe solvent was removed from the filtrate
6. additionthe residue was diluted with water (500 mL)
7. extractionThe aqueous phase was extracted with ether (6×100 mL)
8. custompreabsorbed onto silica gel
9. customchromatographed (19:1 chloroform:methanol, silica)
10. customchromatographed (chloroform to 49:1 chloroform:methanol, silica)

ORD record

ord-fedd994facbc488a82a01cb1876815a6

Source dataset

uspto-grants-1990_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04962224