Hydrochloric Acid → HCID 22162367, compound

HRID 1088931Notes

Reaction equation

HRID 1088931 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1)#[N:2].C([S:14]P(CC)(=S)O)C.[ClH:20]>C(OCC)(=O)C>[ClH:20].[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]([C:1](=[S:14])[NH2:2])=[CH:4]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2302823-CyanoindoleHCID 22162364HCID 22162364, compound

Product 1

HCID 22162367HCID 22162367, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1.0 g of 3-cyanoindole in 30 ml of ethyl acetate was added 1.1 ml of diethyldithiophosphonic acid. The solution was then saturated with gaseous hydrogen chloride and stirred at room temperature for 18 hours. The thioamide was isolated from the reaction mixture as a tan precipitate and used directly in the following reaction.

Sources & evidence

ORD record
ord-8d76ba55745c4dbfb5de77da57ab500e
Source dataset
uspto-grants-1990_10
Patent number
US04963689

Reaction notes

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