反应详情

温度

110 °C

A suspension of 15 g (47.6 mmol) of 2-chloromethyl-1,4-diphenylmethyl piperazine and 8.81 g (47.6 mmol) of potassium phtalimide in 7 ml anhydrous dimethyl formamide was stirred 2 hours at 110° C. After cooling the reaction mixture was taken up with 100 ml ethyl acetate. The mineral salts were filtered off. The solvent was removed, the residue was dissolved in 150 ml ethyl acetate, washed three times with water, dried over magnesium sulfate to give a srystalline product which was resrystallized in isopropyl ether to yield 6.67 g (33%) of title compound. M.P. 124° C.

1. temperatureAfter cooling the reaction mixture
2. filtrationThe mineral salts were filtered off
3. customThe solvent was removed
4. dissolutionthe residue was dissolved in 150 ml ethyl acetate
5. washwashed three times with water
6. dry with materialdried over magnesium sulfate
7. customto give a srystalline product which