2-Chlorobenzoic Acid → 1-(2-Carboxyphenyl)-3-methylindazole

HRID 1089875Notes

Reaction equation

HRID 1089875 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.Cl[C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15].C(=O)([O-])[O-].[K+].[K+]>[Cu]=O>[C:14]([C:13]1[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=1[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([CH3:1])=[N:3]1)([OH:16])=[O:15]

Participants

5

Reactant 3

HCID 83742-Chlorobenzoic AcidHCID 11430Potassium CarbonateHCID 178434273HCID 178434273, compound

Product 1

HCID 199786301-(2-Carboxyphenyl)-3-methylindazoleYield 72.7%

Reagents, catalysts & solvents 1

HCID 14829Copper oxideCatalyst

Procedure

3-Methylindazole (3.30 g), 3.92 g of 2-chlorobenzoic acid, 3.82 g of potassium carbonate and 0.18 g of copper(II) oxide were subjected to reaction in the same manner as in Example 1 to obtain 4.58 g (72.7%) of 1-(2-carboxyphenyl)-3-methylindazole.

Sources & evidence

ORD record
ord-b35b82cfca1b4832919c3839b90b457d
Source dataset
uspto-grants-1992_01
Patent number
US05079358

Reaction notes

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