2-Iodobenzoic acid → HCID 19978635, compound

HRID 1089877Notes

Reaction equation

HRID 1089877 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][N:3]=1.I[C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[C:17]([OH:19])=[O:18].C(=O)([O-])[O-].[K+].[K+]>[Cu]=O>[C:17]([C:16]1[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=1[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=2)[C:2]([CH3:1])=[N:3]1)([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 69412-Iodobenzoic acidHCID 11430Potassium CarbonateHCID 109210543-Methyl-6-nitro-1H-indazole

Product 1

HCID 19978635HCID 19978635, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 14829Copper oxideCatalyst

Procedure

3-Methyl-6-nitroindazole (64.5 g), 46.0 g of 2-iodobenzoic acid, 40.8 g of potassium carbonate and 1.89 g of copper(II) oxide were subjected to reaction in the same manner as in Example 1 to obtain 53.6 g (69.4%) of 1-(2-carboxyphenyl)-3-methyl-6-nitroindazole.

Sources & evidence

ORD record
ord-e6d1e53a56084fdba1d677a616d1ec1b
Source dataset
uspto-grants-1992_01
Patent number
US05079358

Reaction notes

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