Water → HCID 9816434, compound

HRID 1090033Notes

Reaction equation

HRID 1090033 reaction equation
[NH2:1][C:2]1[C:7]2[C:8](=[O:18])[C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[NH:11][C:12](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH3:21]I.O>CN(C)C=O>[NH2:1][C:2]1[C:7]2[C:8](=[O:18])[C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[N:11]([CH3:21])[C:12](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 12517819HCID 12517819, compound

Product 1

HCID 9816434HCID 9816434, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 5 g 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione in 25 ml dimethylformamide are added 0.8 g 60% sodium hydride in mineral oil and then 1.5 ml methyl iodide. After leaving for 24 hours at ambient temperature, with stirring, the mixture is poured into water, filtered and dried: melting point 171°-3° C. (water).

Workup

  1. customAfter leaving for 24 hours at ambient temperature
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-05b27af7e977488f8ee7693661efdd20
Source dataset
uspto-grants-1992_01
Patent number
US05080905

Reaction notes

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