Triethylamine → HCID 14623404, compound

HRID 1090674Notes

Reaction equation

HRID 1090674 reaction equation
C(N(CC)CC)C.[CH:8]1([C:11](Cl)=[O:12])[CH2:10][CH2:9]1.[Cl:14][C:15]1[N:20]=[C:19]([O:21][C:22]2[CH:31]=[CH:30][C:25]([O:26][CH2:27][CH2:28][NH2:29])=[CH:24][CH:23]=2)[CH:18]=[CH:17][CH:16]=1>ClCCl>[Cl:14][C:15]1[N:20]=[C:19]([O:21][C:22]2[CH:31]=[CH:30][C:25]([O:26][CH2:27][CH2:28][NH:29][C:11]([CH:8]3[CH2:10][CH2:9]3)=[O:12])=[CH:24][CH:23]=2)[CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 14623403HCID 14623403, compound

Product 1

HCID 14623404HCID 14623404, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

At room temperature, 1.1 g of triethylamine and then 1.0 g of cyclopropanecarboxylic acid chloride are dripped into 2.6 g of 2-[4-(6-chloropyridin-2-yloxy)-phenoxy]-ethylamine in 50 cm3 of dichloromethane. The reaction is slightly exothermic. The mixture is stirred at room temperature for 14 hours.

Workup

  1. customAt room temperature

Sources & evidence

ORD record
ord-f60adf917b7f49ffabeee70105f5026a
Source dataset
uspto-grants-1992_01
Patent number
US05082852

Reaction notes

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