HCID 15676952, compound → 2-Methoxyethyl piperidin-4-ylcarbamate

HRID 1090693Notes

Reaction equation

HRID 1090693 reaction equation
C1(C[N:8]2[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:21])[O:16][CH2:17][CH2:18][O:19][CH3:20])[CH2:10][CH2:9]2)C=CC=CC=1>C(OCC)(=O)C.[OH-].[Pd+2].[OH-]>[CH3:20][O:19][CH2:18][CH2:17][O:16][C:15](=[O:21])[NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 15676952HCID 15676952, compound

Product 1

HCID 156769702-Methoxyethyl piperidin-4-ylcarbamateYield 97.9%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2-Methoxyethyl (1-phenylmethyl-4-piperidyl)carbamate (9.6 g), prepared according to Preparation 3, was dissolved in ethyl acetate (100 mL). Palladium hydroxide (10% on carbon, 1 g) was added, and the mixture was stirred under hydrogen (1 bar) for 6 hours. The catalyst was removed by filtration, and the solvent evaporated to give 6.5 g of 2-methoxyethyl-4-piperidylcarbamate as an oil, which was used without further purification.

Workup

  1. customaccording to Preparation 3
  2. customThe catalyst was removed by filtration
  3. customthe solvent evaporated

Sources & evidence

ORD record
ord-de19e3f4c7b64de296cf85ef2750c987
Source dataset
uspto-grants-1992_01
Patent number
US05082847

Reaction notes

Loading…