Hydrochloric Acid → 3,3-dimethoxypropanoic Acid

HRID 1090701Notes

Reaction equation

HRID 1090701 reaction equation
[CH3:1][O:2][CH:3]([O:9][CH3:10])[CH2:4][C:5]([O:7]C)=[O:6].Cl>[OH-].[Na+].O>[CH3:1][O:2][CH:3]([O:9][CH3:10])[CH2:4][C:5]([OH:7])=[O:6]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 81924Methyl 3,3-dimethoxypropionate

Product 1

HCID 103745043,3-dimethoxypropanoic AcidYield 79.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

50 g (0.33 mol.) of Methyl 3,3-dimethoxy-propanoate in 200 ml of 2N NaOH solution in water were refluxed 2 hours. After cooling the solution was acidified with hydrochloric acid then extracted two times with 200 ml of CH2Cl2. The extracts were dried on sodium sulfate and evaporated to leave 35 g (Yield=78%) of 3,3-dimethoxy-propanoic acid as an oil.

Workup

  1. temperatureAfter cooling the solution
  2. extractionthen extracted two times with 200 ml of CH2Cl2
  3. customThe extracts were dried on sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-8da6dea0eb444563af2b044a97b7fe22
Source dataset
uspto-grants-1992_01
Patent number
US05082847

Reaction notes

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