反应详情

50 g (0.33 mol.) of Methyl 3,3-dimethoxy-propanoate in 200 ml of 2N NaOH solution in water were refluxed 2 hours. After cooling the solution was acidified with hydrochloric acid then extracted two times with 200 ml of CH2Cl2. The extracts were dried on sodium sulfate and evaporated to leave 35 g (Yield=78%) of 3,3-dimethoxy-propanoic acid as an oil.

1. temperatureAfter cooling the solution
2. extractionthen extracted two times with 200 ml of CH2Cl2
3. customThe extracts were dried on sodium sulfate
4. customevaporated