Hydrochloric Acid → HCID 57868321, compound

HRID 1091314Notes

Reaction equation

HRID 1091314 reaction equation
C([O:3][C:4](=[O:25])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([C:15]2[C:16]3[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=3[O:18][CH:19]=2)=[O:14])=[C:8]([Cl:24])[CH:7]=1)C.[OH-].[Na+].Cl>O1CCCC1.CO>[O:18]1[CH:19]=[C:15]([C:13]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([CH2:5][C:4]([OH:25])=[O:3])=[CH:7][C:8]=2[Cl:24])=[O:14])[C:16]2[CH:23]=[CH:22][CH:21]=[CH:20][C:17]1=2

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66592220HCID 66592220, compound

Product 1

HCID 57868321HCID 57868321, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

[4-[(Benzo[b]furan-3-ylcarbonyl)amino]-3-chlorophenyl]acetic acid ethyl ester (2.08 g, 5.81 mmol) was dissolved in tetrahydrofuran (15 mL) and methanol (5 mL), and a 1N-aqueous solution of sodium hydroxide (11.60 mL, 11.60 mmol) was added thereto. The mixture was stirred for three hours at room temperature. The reaction liquor was poured onto ice-1N-hydrochloric acid, and precipitated solids were collected by filtration, and dried under reduced pressure, to obtain the title compound (1.70 g, 89%) as a solid.

Workup

  1. customprecipitated solids
  2. filtrationwere collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-df4378a3bf3a47808998ceddf6a4e95b
Source dataset
uspto-grants-2012_03
Patent number
US08129366B2

Reaction notes

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