反应详情

To 6-chloro-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (0.418 mmol), NaH (60% in oil, 2.1 mmol) and ethyl iodide (2.1 mmol) is added N-methylpyrrolidinone (1 mL). After 5 min the reaction mixture is heated in the microwave at 175 C for 10 min. Reverse phase HPLC gave the product.

1. temperatureAfter 5 min the reaction mixture is heated in the microwave at 175 C for 10 min
2. customReverse phase HPLC gave the product