3-Pentanamine → HCID 25115069, compound

HRID 1094058Notes

Reaction equation

HRID 1094058 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[C:18]2[C:17](=[O:19])[N:16]([CH3:20])[C:15](=[O:21])[N:14]([CH3:22])[C:13]=2[N:12]=[C:11](Cl)[C:10]=1[C:24]#[N:25].[CH3:26][CH2:27][CH:28]([NH2:31])[CH2:29][CH3:30].[C:32]([O-])(O)=[O:33].[Na+]>C(O)(C)C>[NH2:25][CH2:24][C:10]1[C:11]([NH:31][CH:28]([CH2:29][CH3:30])[CH2:27][CH3:26])=[N:12][C:13]2[N:14]([CH3:22])[C:15](=[O:21])[N:16]([CH3:20])[C:17](=[O:19])[C:18]=2[C:9]=1[C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[O:33][CH3:32]

Participants

5

Reactant 3

HCID 120193-PentanamineHCID 516892Sodium BicarbonateHCID 11683267HCID 11683267, compound

Product 1

HCID 25115069HCID 25115069, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The title compound was prepared from Compound 47a (Example 42, 1 equiv), pentan-3-amine (3 equiv) and NaHCO3 (5 equiv) in isopropanol under micro wave condition at 180° C. for 30 min, and purified by LC-MS. MS [m+H] calc'd C22H29FN5O3 430; found 430.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-7990a48f27404d08a410b956f3ea9c20
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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