Potassium Carbonate → HCID 57743275, compound

HRID 1095099Notes

Reaction equation

HRID 1095099 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:11]([O:22][CH3:23])(=[O:21])[C:12]1[CH:20]=[CH:19][C:17]([OH:18])=[C:14]([O:15][CH3:16])[CH:13]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[CH3:23][O:22][C:11](=[O:21])[C:12]1[CH:20]=[CH:19][C:17]([O:18][C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=2[CH:7]=[O:8])=[C:14]([O:15][CH3:16])[CH:13]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 19844Methyl VanillateHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 57743275HCID 57743275, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-bromo-2-fluorobenzaldehyde (4.1 g, 20 mmol) (Alfa) was reacted with methyl vanillate (3.64 g, 20 mmol)(Aldrich) and K2CO3 in N,N-dimethylacetamide to give 4-(4-bromo-2-formyl-phenoxy)-3-methoxy-benzoic acid methyl ester as a white solid (Yield 3.1 g, 92%).

Sources & evidence

ORD record
ord-d4bf962d08144622b8ca4e46d1722d29
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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